Once upon a time one famous journal published a new piece of meta-research into the relative effectiveness of Orlistat, Meridia and Acomplia. The main problem is that if you want to achieve the only one number, you must make at least 200 experiments on people. Although these studies have to be “statistically significant”, i.e. it must be reasonable to scale up the results so that they will offer a reasonable chance of being replicated in the community at large, one study cannot be anything more than an indicator. To get the best results, you need to take a number of published clinical trials and reanalyse the data to determine whether there are trends. This is what a meta-researcher does.

Hence the team analysed the data from thirty clinical trials representing 19,619 participants. Each of these trials had to last at least one year to be included in analysis, the treatment with the medication had to be in conjunction with lifestyle changes to diet and encourage physical exercise, and follow the best practice methods of being randomised, double blind and placebo-controlled. Thus, the data covers a reasonable period of time (the longer the period of time, the more people are likely to drop out of trials - in this instance, an average of about 35% of the participants dropped out), and a more significant number of people.

The participants taking Acomplia had the highest range of weight loss at 4.1kg to 5.3kg. It also reduced the levels of high density lipoprotein cholesterol and triglycerides, improved blood pressure, and in patients with diabetes, gave better glycaemic control. But Acomplia was associated with a risk of anxiety, irritability and depression in about 6% of participants.

The National Institute for Health and Clinical Excellence (NICE) has recently changed its recommendation to accept Acomplia as being within National Health Service guidelines. The relevant rule for acceptance as an anti-obesity medication is that patients should consistently be able to lose at least 5% of their initial body weight after three months. That Acomplia has now satisfied this performance criterion is an endorsement of the medication’s effectiveness.

Let us be clear - a 5% average may include people who failed completely and put weight on because they resisted change to their diet and refused exercise. If people cannot reduce some weight through their own efforts, giving them a pill like Acomplia is not going to help. A 5% average may therefore include some people who have lost between 10% and 20%. Given that some 35% of participants in the clinical trials lacked the motivation to continue, that means that 65% were sufficiently encouraged by the performance of their medication to continue to the end of the agreed period. Add in the significant improvement among diabetics, and Acomplia begins to look even better. However, given the risk of psychological side effects, it is perhaps always wise to take Acomplia when you are in a family environment or you have friends who can be relied on to monitor your mood.

So the moral of the research alongside NICE’s change of policy is that if you are sufficiently motivated to lose weight by changing your diet and exercising more, Acomplia will significantly improve your chances of losing weight and maintaining that reduction over time.

If we know the person, the death can be a load that some cannot carry without the help of something like Xanax. Then comes Heath Ledger - a man who lived his life in the public eye. It was like we all knew him - so alive one minute; so uncompromisingly dead the next. A few days after his discovery on the 22nd January 2008, the Medical Examiner’s Report was published. Heath was relying on Xanax to keep him going. Let’s not judge him. Who is to say where the dividing line between genius and madness lies, nor how anyone stays on the right side of that line without help.

The medical profession define social anxiety disorder as extreme anxiety about facing the judgement of others or behaving in a way that might cause you embarrassment or ridicule. How would you react if, everywhere you look or turn, you find a camera’s intrusive lens hoping to catch you in a moment that will sell a million magazines? Even the ordinary becomes the potentially extraordinary depending on how the camera captures it (and how some software package can manipulate it to make it more exploitable). When you know that anything you do or say can and will be misinterpreted for another’s profit, is it any surprise that you reach for Xanax? I think not.

In fact, the whole movie industry is probably built on Xanax. Feeling nervous or anxious before you set foot outside your front door knowing you’ll be stalked by photographers wherever you go? Take a Xanax. That’s not agoraphobia threatening to keep you hiding away, is it? Take another Xanax. The next magazine you open has pictures of you getting (un)dressed in your bedroom. They were taken with a telephoto lens from the building opposite. That’s not the first sign of a panic attack is it? Draw the curtains and take another Xanax just to keep on living.

But you need the relationship between public and private to stay blurred. To carry the films, your name has to be on everyone’s lips. You have to be the eye candy for the media voyeurism. Drop from those celebrity magazines and gossip columns, and you’re no longer the bankable star. Where can you buy Xanax without someone taking a picture of you? Buy Xanax online. But Heath lost control, mixed his medications, took too much, and paid the price. Let that be a warning to you all. Stay alive by keeping control of your intake of Xanax and any other medications.

The one consolation in all this is that, even though Xanax was not able to keep poor Heath going, we still have the next Batman film to look forward to. By all accounts, Heath’s performance as the Joker in the Dark Knight is well worth the price of entry. Although there’s perhaps something inherently ironic about Xanaxman playing the Joker. Here’s a character so completely over-the-top, so excessive in his nature with all that malicious glee bubbling over into destructive energy. Did Heath have to take Xanax to act the part of someone who so obviously doesn’t take Xanax?

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